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Cbd Oil And The Endocannabinoid System 101

Since then scientists have learned more and more about the way this incredible system affects our bodies. From regulating pain receptors to stimulating serotonin levels, the endocannabinoid system has an impact on our lives every day.

All neurons contain multiple receptors and can respond to some neurotransmitters but not others. The first thing to know is that the endocannabinoid system is made up of receptors that interact with THC and CBD, collectively known as cannabinoids, and is just starting to really be studied by researchers. Refer to Figure 2 to see areas of the brain with cannabinoid receptors, then locate those areas on the chart to study some of the different effects of THC on the user. When these external cannabinoids are ingested, they interact with CB1 and CB2 receptors in similar ways as endogenous cannabinoids. By doing this, phytocannabinoids can actually boost the endocannabinoid system andhelp it functiondifferently or even more effectively than it can on its own.

The ECS’s CB1 receptor, primarily found in the brain, is the same receptor that THC binds to. We’ll also discuss how external cannabinoids, like THC and CBD, interact with your body’s own cannabinoid receptors. CBD does not directly bind and activate the cannabinoid receptors the way other cannabinoids can. For instance, THC will bind and activate CB1 receptors in the brain, which will then produce the “high” people feel when using marijuana.

There are two main types of receptors which are present throughout the body – the CB1 receptor and the CB2 receptor. The CB1 receptor is the most prominent and is found in the brain, central nervous system, reproductive system, cardiovascular system, and the liver, among others. The CB2 receptor is more scarce and is found mostly in peripheral systems. The CB2 receptor, however, still plays a very important role in the endocannabinoid system.

THC and CBD are the two major cannabinoids of interest to the scientific community as they are responsible for several effects possible from Cannabis Concentrates usage. Some types of medical marijuana contain a high concentration of THC, CBD oil which is why doctors have reservations to prescribe it for users with mental ailments. It simply delivers the many health benefits to its users without any high. It can be considered one of the many reasons behind the expanding popularity of the substance.

This discovery was quickly followed up with further evidence by Dr. Raphael Mechoulam, the famous chemist who discovered THC. With less than 30 years of research, the endocannabinoid system is one of the less studied systems in the body. Currently, restrictions on cannabis research limit what scientists can examine in terms of furthering our understanding of how cannabis interacts with the endocannabinoid system. Highly specialized brain cells, also known as “neurons,” are connected to each other by synapses, or communication sites where neurotransmitters are released. Neurons only receive a specific message if they have a receptor that fits the neurotransmitter, much like a socket fits a plug.

• Stimulation of the endocannabinoid system could be useful in the treatment of PTSD, as it is for treatments of cachexia and spasticity.
• Failure to extinguish learned fearful responses may underlie posttraumatic stress syndrome in humans.
• Normal coping includes dissipation of the bad memories evoked by the tone , a process called “extinction,” which enables animals to cease paying the high costs of pointless responding.
• From a therapeutic point of view, the near ubiquity of the endocannabinoid system has good news/bad news implications.
• Varma N, Carlson GC, Ledent C, Alger BE. Metabotropic glutamate receptors drive the endocannabinoid system in hippocampus.

Although CBD does perform multiple actions in the body, its best-known function in the ECS is its potential to inhibit the activity of the enzyme called fatty acid amide hydrolase . FAAH breaks down anandamide, one of the body’s endogenous cannabinoids, which is known to bind to the ECS’s CB1 receptor.

It results in the regulation of receptor activities that initiates anti-inflammatory benefits to users. The cannabis plant is slowly spreading its wings into several applications. Scientists found that the benefits possible from the cannabis plant are due to the presence of active compounds referred to as cannabinoids.

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